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Preventing Heart Disease and Stroke: CSU receives $445,500 NIH grant to improve treatment of atherosclerosis

CLEVELAND, February 11, 2019: Atherosclerosis, the narrowing of the arteries due to the build-up of plaque, is a primary cause of heart disease and stroke. Unfortunately, there are currently few preventative treatments that can decrease or eliminate atherosclerosis.

Through a new grant from the National Institutes of Health, Cleveland State University is investigating the effect of a key enzyme on plaque build-up, which could be central to developing effective genetic therapies for addressing the condition.

Aimin Zhou, a professor in the Department of Chemistry and a member of CSU’s Center for Gene Regulation in Health and Disease, has received a $445,500 Academic Research Enhancement Award from NIH to improve understanding of how the enzyme RNase L contributes to atherosclerosis in humans. The data will ultimately be used to create better genetic treatments to reduce the impact of atherosclerosis on cardiovascular health. The effort will build on previous research conducted by Zhou which indicates decreasing the level of RNase L can lead to an increase in plaque build-up.

For more information about Zhou’s research, visit https://www.csuohio.edu/grhd/faculty/aimin-zhou.



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Revised: 02/19/19 10:24:48 -0800.




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